慢性阻塞性肺疾病急性加重相关的免疫细胞及因子研究进展
Research progress of immunocytes and immunologic factors related to acute exacerbation of chronic obstructive pulmonary disease
- 解放军医学杂志 2023年48卷第11期 页码：1353-1358
- 作者机构：
1.河北北方学院研究生学院，河北张家口 075000
2.解放军总医院第八医学中心呼吸与危重症医学部研究所/北京市器官移植与免疫调节重点实验室，北京 100091
- 作者简介：
李蕊，硕士研究生，主要从事肺疾病实验室检验诊断方面的研究
肖漓，E-mail：xiaolilab309@163.com
- 基金信息：首都卫生发展科研自主创新专项(2022-2-5092)
DOI：10.11855/j.issn.0577-7402.1493.2023.0413
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李蕊, 肖漓. 慢性阻塞性肺疾病急性加重相关的免疫细胞及因子研究进展[J]. 解放军医学杂志, 2023, 48(11): 1353-1358.
Li Rui,Xiao Li.Research progress of immunocytes and immunologic factors related to acute exacerbation of chronic obstructive pulmonary disease[J].Medical Journal of Chinese People′s Liberation Army,2023,48(11):1353-1358.
李蕊, 肖漓. 慢性阻塞性肺疾病急性加重相关的免疫细胞及因子研究进展[J]. 解放军医学杂志, 2023, 48(11): 1353-1358. DOI： 10.11855/j.issn.0577-7402.1493.2023.0413.
Li Rui,Xiao Li.Research progress of immunocytes and immunologic factors related to acute exacerbation of chronic obstructive pulmonary disease[J].Medical Journal of Chinese People′s Liberation Army,2023,48(11):1353-1358. DOI： 10.11855/j.issn.0577-7402.1493.2023.0413.
摘要
慢性阻塞性肺疾病(COPD)是呼吸系统的多发病和常见病，且一直存在早期诊断率低、治疗依从性低、治疗规范性低等问题。临床实践显示，COPD的异质性是其治疗困难的原因之一。近年来逐渐认识到COPD的发生发展与机体免疫状态密切相关，多项研究试图寻找特异性强、灵敏度高的细胞与分子生物标记物，以早期诊断COPD急性加重并进行亚型区分，为COPD患者提供个体化的诊疗策略。本文综述近年来与不同表型COPD及疾病进展密切相关的免疫细胞及因子作为生物标志物的研究进展，旨在为COPD的诊断与治疗研究提供参考。
Abstract
Chronic obstructive pulmonary disease (COPD) is a frequent and common disease of the respiratory system. The problem of low early diagnosis rate, low treatment compliance, and low treatment standardization has persisted in the diagnosis and treatment of COPD. Heterogeneity found in clinical practice is one of the reasons why COPD is difficult to treat. In recent years, it has been gradually recognized that the occurrence and development of COPD are closely related to the immune state of the body. At present, it become one of the hot spots in clinical and basic research that searching for specific and sensitive cell and molecular biomarkers to early diagnose acute exacerbation and subtype differentiation of COPD, which ultimately provide individual diagnosis and treatment strategies for COPD patients. This review focuses on the research progress of immunocytes and immunologic factors as biomarkers to different phenotypes and progression of COPD in recent years, providing a reference for the research on diagnosis and treatment of COPD.
关键词
慢性阻塞性肺疾病急性加重期免疫细胞免疫因子生物标志物
Keywords
acute exacerbation of chronic obstructive pulmonary disease (AECOPD)immunocyteimmunologic factorbiomarker
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