Comparison of neuroprotective effects of hUC-MSCs-Exos on hypoxic-ischemic brain injury in neonatal mice by different administration modes

Hu Xiao-Xia; Sai Yi-Pa; Chen Xing-Xing; Cui Wei-Jing; Wang San-Ping; Luo Xuan; Wu Shi-Li

doi:10.11855/j.issn.0577-7402.1084.2024.1118

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Comparison of neuroprotective effects of hUC-MSCs-Exos on hypoxic-ischemic brain injury in neonatal mice by different administration modes

Medical Journal of Chinese People′s Liberation Army Vol. 50, Issue 2, Pages: 207-213(2025)

Basic Research | 更新时间：2025-03-10

- Comparison of neuroprotective effects of hUC-MSCs-Exos on hypoxic-ischemic brain injury in neonatal mice by different administration modes
- “The latest research has found that extracellular vesicles derived from human umbilical cord blood mesenchymal stem cells have an improving effect on neurological function in mice with hypoxic-ischemic brain injury, and the effect is better when administered through the nasal cavity, which is convenient for clinical application.”
- 作者机构：
  
  甘肃省人民医院/甘肃中医药大学第一临床医学院儿科，甘肃兰州　730030
- 作者简介：
  
  E-mail: suade10@sohu.com
- 基金信息：
  
  the Natural Science Foundation of Gansu Province(22JR5RA689);the Gansu Youth Science and Technology Fund Project(22JR5RA701);the Key Laboratory of Molecular Diagnosis and Precision Therapy of Surgical Tumor of Gansu Province(GSSZDSYS2020-10);the Research Foundation of People's Hospital of Gansu Province(20GSSY1-13)
- DOI：10.11855/j.issn.0577-7402.1084.2024.1118
  CLC： R722.12
- Received：15 August 2023，
  
  Accepted：2023-10-12，
  
  Published Online：18 November 2024，
  
  Published：28 February 2025
- 稿件说明：
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胡筱霞, 赛依帕, 陈星星, 等. hUC-MSCs-Exos不同给药方式对缺氧缺血性脑损伤新生小鼠的神经保护作用[J]. 解放军医学杂志, 2025, 50(2): 207-213.

Hu Xiao-Xia,Sai Yi-Pa,Chen Xing-Xing,et al.Comparison of neuroprotective effects of hUC-MSCs-Exos on hypoxic-ischemic brain injury in neonatal mice by different administration modes[J].Medical Journal of Chinese People′s Liberation Army,2025,50(02):207-213.
胡筱霞, 赛依帕, 陈星星, 等. hUC-MSCs-Exos不同给药方式对缺氧缺血性脑损伤新生小鼠的神经保护作用[J]. 解放军医学杂志, 2025, 50(2): 207-213. DOI： 10.11855/j.issn.0577-7402.1084.2024.1118.

Hu Xiao-Xia,Sai Yi-Pa,Chen Xing-Xing,et al.Comparison of neuroprotective effects of hUC-MSCs-Exos on hypoxic-ischemic brain injury in neonatal mice by different administration modes[J].Medical Journal of Chinese People′s Liberation Army,2025,50(02):207-213. DOI： 10.11855/j.issn.0577-7402.1084.2024.1118.

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Comparison of neuroprotective effects of hUC-MSCs-Exos on hypoxic-ischemic brain injury in neonatal mice by different administration modes

DOI：10.11855/j.issn.0577-7402.1084.2024.1118