The role of matrix metalloproteinase 3 to progression of pulmonary fibrosis in mouse silicosis
Medical Journal of Chinese People′s Liberation ArmyVol. 50, Issue 4, Pages: 458-466(2025)
Basic Research|更新时间:2025-05-16
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The role of matrix metalloproteinase 3 to progression of pulmonary fibrosis in mouse silicosis
“The latest research found that in the silicosis model of mice induced by silica, TGF - β 1 led to the increase of MMP3 secreted by fibroblasts and retention in pulmonary ECM, which aggravated collagen deposition and promoted pulmonary fibrosis. MMP3 may become a potential therapeutic target for silicosis fibrosis.”
作者机构:
1.东南大学公共卫生学院/环境医学工程教育部重点实验室,江苏南京 210009
2.东南大学医学院医学生理系,江苏南京 210009
作者简介:
E-mail: chaojie@seu.edu.cn
基金信息:
the National Natural Science Foundation of China(82373547)
Wang Yu-Meng,Luo Wei,Chao Jie.The role of matrix metalloproteinase 3 to progression of pulmonary fibrosis in mouse silicosis[J].Medical Journal of Chinese People′s Liberation Army,2025,50(04):458-466.
Wang Yu-Meng,Luo Wei,Chao Jie.The role of matrix metalloproteinase 3 to progression of pulmonary fibrosis in mouse silicosis[J].Medical Journal of Chinese People′s Liberation Army,2025,50(04):458-466. DOI: 10.11855/j.issn.0577-7402.0920.2024.1227.
The role of matrix metalloproteinase 3 to progression of pulmonary fibrosis in mouse silicosis