Quick Entry
About Journal
Editor-in-chief Fu Xiao-Bing
Directed by Academy of Military Sciences
Sponsored by Military Sciences Publishing House
Periodical No. ISSN 0577-7402 CN 11-1056/R
Address: Building No. 75, 22 Fuxing Road, Haidian District, Beijing 100842, China
Tel(Fax) 010-51927306, 010-51927307
- Latest Articles
- Online First
- Archive
2026年第51卷第6期
Guideline and Consensus
摘要：Acute abdomen is common critical and severe condition encountered in the emergency department. Owing to its complex etiologies, abrupt onset, rapid progression, and high risk of misdiagnosis and missed diagnosis, standardized evaluation and timely management remain major focuses and difficulties in clinical practice. This expert consensus was jointly developed by the Chinese Medical Doctor Association Emergency Medical Branch, Chinese PLA Emergency Medicine Professional Committee, Beijing Emergency Medicine Society, Emergency Surgery Alliance, Emergency Physicians Branch of Hubei Medical Doctor Association. Focusing on key clinical issues in the diagnosis and treatment of acute abdomen in adults, a systematic literature search was conducted based on the "6S" evidence model, with the search period extending from database inception to October 13, 2025. The quality of evidence and strength of recommendations were graded using the Grading of Recommendations Assessment, Development and Evaluation (GRADE) system. This consensus covers epidemiological characteristics, early recognition and risk stratification, laboratory and imaging evaluation, initial resuscitation and analgesia, anti-infective therapy, selection of surgical timing and methods, as well as diagnosis and treatment strategies for special populations including elderly patients, immunocompromised patients, and tumor patients. It emphasizes the important role of multidisciplinary collaboration in optimizing the diagnosis and treatment process, improving therapeutic efficiency and patient prognosis, and aim to provide emergency physicians with evidence-based, practical, and standardized clinical guidance.关键词：acute abdomen;adult;diagnosis;treatment;multidisciplinary team;expert consensus2006|0|0更新时间：2026-07-15Expert Review
摘要：Inflammatory vitreoretinal disease (IVRD) is a group of blinding disorders with significant heterogeneity, which is based on the common pathological basis of immune-inflammatory injury in the posterior segment. Its clinical spectrum includes infectious and noninfectious uveitis, as well as some retina/choroid disorders driven by inflammation. In recent years, the diagnosis and treatment model of IVRD has been shifting from empirical inflammation control to mechanism-based precision management. On the diagnostic side, methods such as polymerase chain reaction, metagenomic sequencing, cytokine profiling, and immunogenetic markers have significantly improved the ability of etiologic identification and immune phenotyping. On the therapeutic side, sustained-release corticosteroids, suprachoroidal drug delivery, anti-tumor necrosis factor α (anti-TNF-α), anti-interleukin 6 receptor (anti-IL-6R) biologics, and Janus kinase (JAK) inhibitors have improved the control rate of refractory disease, while exosomes, nanocarriers, and gene-editing delivery systems are promoting the development of posterior segment therapy toward long-acting, minimally invasive, and targeted directions. The main bottlenecks at this stage are the lack of unified disease naming and stratification, insufficient clinical translation of biomarkers, and most innovative therapies remaining in the early research stage. This review aims to systematically summarize the latest advances in the diagnosis and treatment of IVRD, focusing on the application progress of molecular diagnosis, immune marker testing, and emerging therapeutic technologies. Meanwhile, it addresses the main challenges in the current treatment of IVRD, such as the lack of unified disease classification and insufficient clinical translation of biomarkers, and proposes that the future direction of precision medicine should focus on constructing evidence-based pathways around "precise stratification-targeted drug delivery-long-term safety evaluation" to improve visual function outcomes and reduce the risks of recurrence and blindness.关键词：inflammatory vitreoretinal disease;immune markers;targeted therapy;biological agents1810|0|0更新时间：2026-07-15Clinical Research
摘要：ObjectiveTo investigate the association between life's essential 8 (LE8) score and cognitive impairment in elderly patients with H-type hypertension, as well as the correlation and interactive role of high-sensitivity C-reactive protein (hs-CRP).MethodsClinical data of 512 elderly patients with H-type hypertension admitted to the Second Medical Center of Chinese PLA General Hospital in Beijing from June 2020 to June 2025 were retrospectively analyzed. Patients were divided into cognitive impairment group (n=225) and control group (n=287) according to their cognitive status. Baseline characteristics were compared between the two groups. Multivariate logistic regression was performed to identify independent risk factors for cognitive impairment. Patients were further stratified by hs-CRP levels, and weighted stepwise logistic regression was applied to analyze the association between LE8 score and cognitive impairment across different strata.ResultsRisk factors for cognitive impairment in elderly patients with H-type hypertension included age increases (OR=1.087, 95%CI 1.006-1.172), comorbid hyperlipidemia (OR=1.739, 95%CI 1.125-3.994), low LE8 score (OR=0.864, 95%CI 0.621-0.953), and high hs-CRP (OR=1.215, 95%CI 1.052-1.403, P<0.05). Correlation analysis revealed a significant negative association between LE8 score and hs-CRP level (β=-0.148, 95%CI -0.209 to -0.087, P<0.001). After stratifying patients into low and high hs-CRP groups and adjusting for confounders, each 10-point increase in LE8 score was associated with a significant reduction in the risk of cognitive impairment in both groups (low hs-CRP group: OR=0.66, 95%CI 0.59-0.75; high hs-CRP group: OR=0.85, 95%CI 0.66-0.94, P<0.05). Moreover, the protective effect was 19% greater in low hs-CRP group than high hs-CRP group.ConclusionBoth LE8 score and hs-CRP are associated with cognitive impairment in elderly H-type hypertension patients. The inverse association between LE8 score and cognitive impairment is more pronounced in patients with lower hs-CRP levels.关键词：hypertension;homocysteine;cognitive impairment;life's essential 8 score;high-sensitivity C-reactive protein1472|0|0更新时间：2026-07-15-
Nomogram for overall survival in elderly patients with pancreatic cancer and liver metastasis 增强出版 AI导读
摘要：ObjectiveTo establish a nomogram prediction model for predicting the overall survival (OS) of elderly patients (≥60 years old) with pancreatic cancer and liver metastasis.MethodsClinical data of all elderly patients with pancreatic cancer and liver metastasis from 2010 to 2020 were retrieved from the Surveillance, Epidemiology, and End Results (SEER) database. The patients were randomly divided into a training set and a verification set at a ratio of 7:3. Univariate and multivariate Cox regression analyses were performed to identify independent prognostic factors for OS in these patients, which were further verified by Kaplan-Meier survival analysis with survival curves plotted. A nomogram was constructed based on the identified independent prognostic factors to predict the 6-month, 12-month and 18-month survival probabilities of elderly patients with pancreatic cancer and liver metastasis. The discrimination ability of the model was evaluated using the receiver operating characteristic (ROC) curve and area under the curve (AUC). Calibration curves were used to assess the accuracy of the model, and decision curve analysis (DCA) was conducted to evaluate its potential clinical application value.ResultsA total of 1424 elderly patients with pancreatic cancer and liver metastasis were enrolled, including 356 survivors (25.0%) and 1068 non-survivors (75.0%). They were randomly divided into a training set (n=996) and a validation set (n=428) at a 7:3 ratio, with balanced and comparable baseline characteristics between the two groups (P>0.05). Multivariate Cox regression analysis showed that T stage, N stage, surgery, chemotherapy, lung metastasis, and other distant metastases were independent prognostic factors for OS (P<0.05): the risk of death in T2 and T3 stages was 1.83 times (95%CI 1.30-2.58) and 1.88 times (95%CI 1.34-2.64) higher than that in T1 stage, respectively; the risk of death in N1 stage was reduced by 47% compared with N0 stage (HR=0.53, 95%CI 0.37-0.78); surgery and chemotherapy could reduce the risk of death by 59% and 70%, respectively (HR=0.41, 95%CI 0.25-0.68; HR=0.30, 95%CI 0.25-0.35); the risk of death was increased by 51% and 28% in patients with lung metastasis and other distant metastases, respectively (HR=1.51, 95%CI 1.22-1.87; HR=1.28, 95%CI 1.05-1.55). The nomogram constructed based on the above factors was used to predict OS at 6, 12, and 18 months. The AUC values of training set were 0.83, 0.82, and 0.80, respectively, while those of validation set were 0.84, 0.80, and 0.78, respectively, indicating good discriminative ability. Calibration curves showed a high consistency between predicted and actual survival probabilities. DCA indicated that the model yielded positive net benefits within the risk threshold of 0.40-0.95, which was superior to the strategies of full intervention or no intervention, suggesting favorable potential clinical application value.ConclusionThe established nomogram can be used to predict the OS of elderly patients with pancreatic cancer and liver metastasis, which will be useful for individualized survival assessment and clinical management of these patients.关键词：elderly patients;pancreatic cancer;liver metastasis;overall survival;nomogram1435|1088|0更新时间：2026-07-15
查看更多
更多
- Technical support is provided by Beijing Founder electronics co., LTD 京ICP备09064830号-19
京公网安备11010802024621 - It is recommended to read the content of this site in Chrome&IE9+. Please switch to extreme mode in browser 360.
- Cookies We use cookies to help provide and enhance our service and tailor content. By continuing, you agree to the use of cookies.
0