Protective mechanism of lycium barbarum polysaccharide against pyroptosis in APP/PS1 mice <italic style="font-style: italic">via</italic> modulating the NLRP3 inflammasome

Jia Si-Wei; Guo Min-Fang; Dai Hui-Min; Chen Jia-Yuan; Wang Ji-Wei; Meng Tao; Ma Cun-Gen; Yu Jie-Zhong

doi:10.11855/j.issn.0577-7402.2073.2026.0121

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Protective mechanism of lycium barbarum polysaccharide against pyroptosis in APP/PS1 mice via modulating the NLRP3 inflammasome

Medical Journal of Chinese People′s Liberation Army Vol. 51, Issue 4, Pages: 576-585(2026)

Basic Research | 更新时间：2026-05-15

- Protective mechanism of lycium barbarum polysaccharide against pyroptosis in APP/PS1 mice via modulating the NLRP3 inflammasome
- 作者机构：
  
  1.山西中医药大学神经生物学研究中心/国家中医药管理局多发性硬化益气活血重点研究室/基于炎性反应的重大疾病创新药物山西省重点实验室，山西晋中　030619
  2.山西大同大学脑科学研究所/分子细胞免疫学大同市重点实验室，山西大同 037009
  3.山西大同大学附属第一医院/大同市第五人民医院神经医学中心，山西大同 037056
- 作者简介：
  
  Ma Cun-Gen, E-mail: macungen@sxtcm.edu.cn
  Yu Jie-Zhong, E-mail: sxdtyjz@qq.com
- 基金信息：
  
  the Shanxi Province Basic Research Program(202303021211244);the "Four Batches" Science and Technology Innovation Plan Project of Shanxi Province(2022XM33);the Shanxi Province Chinese Medicine Scientific Research Topic Program(2023ZYYB2042);the State Administration of Traditional Chinese Medicine Scientific Research Topic(2023ZYYDA2038)
- DOI：10.11855/j.issn.0577-7402.2073.2026.0121
  CLC： R285.5;R392.5;R741.02
- Received：01 October 2025，
  
  Accepted：01 December 2025，
  
  Published：28 April 2026
- 稿件说明：
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贾思玮, 郭敏芳, 代慧敏, 等. 枸杞多糖调节NLRP3炎症小体对APP/PS1小鼠细胞焦亡的影响及其机制[J]. 解放军医学杂志, 2026, 51(4): 576-585.

Jia Si-Wei,Guo Min-Fang,Dai Hui-Min,et al.Protective mechanism of lycium barbarum polysaccharide against pyroptosis in APP/PS1 mice via modulating the NLRP3 inflammasome[J].Medical Journal of Chinese People′s Liberation Army,2026,51(04):576-585.
贾思玮, 郭敏芳, 代慧敏, 等. 枸杞多糖调节NLRP3炎症小体对APP/PS1小鼠细胞焦亡的影响及其机制[J]. 解放军医学杂志, 2026, 51(4): 576-585. DOI： 10.11855/j.issn.0577-7402.2073.2026.0121.

Jia Si-Wei,Guo Min-Fang,Dai Hui-Min,et al.Protective mechanism of lycium barbarum polysaccharide against pyroptosis in APP/PS1 mice via modulating the NLRP3 inflammasome[J].Medical Journal of Chinese People′s Liberation Army,2026,51(04):576-585. DOI： 10.11855/j.issn.0577-7402.2073.2026.0121.

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Protective mechanism of lycium barbarum polysaccharide against pyroptosis in APP/PS1 mice via modulating the NLRP3 inflammasome

DOI：10.11855/j.issn.0577-7402.2073.2026.0121