Chinese expert consensus on the rational use of prothrombin complex concentrate in critically ill patients

Song Jing-Chun; Wang Gang; Fang Yun-Hai; Wu Hai-Ying; Yin Hai-Yan; Zhang Jin-Hua; Ke-Lu; Ding Ren-Yu; Zhou Zhou; Chinese Society of Thrombosis; Hemostasis and Critical; Chinese Medicine Education Association, People's Liberation Army Professional Committee of Critical Care Medicine, Chinese Society of Thrombosis and Hemostasis, Chinese Research Hospital Association

doi:10.11855/j.issn.0577-7402.1079.2023.1103

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Chinese expert consensus on the rational use of prothrombin complex concentrate in critically ill patients

Guideline and Consensus | 更新时间：2024-01-04

- Chinese expert consensus on the rational use of prothrombin complex concentrate in critically ill patients
- Medical Journal of Chinese People′s Liberation Army Vol. 48, Issue 12, Pages: 1359-1369(2023)
- 作者机构：
  
  1.解放军联勤保障部队第908医院重症医学科，江西南昌　330002
  2.西安交通大学第二附属医院重症医学科，陕西西安　710004
  3.山东省血液中心血友病诊疗中心，山东济南　250013
  4.昆明医科大学第一附属医院急诊科，云南昆明　650032
  5.暨南大学附属第一医院重症医学科，广东广州　510630
  6.福建省妇幼保健院药学科，福建福州　350005
  7.东部战区总医院重症医学科，江苏南京　210002
  8.中国医科大学附属第一医院重症医学科，辽宁沈阳　110001
  9.中国医学科学院阜外医院检验科，北京　100037
- 作者简介：
  
  E-mail: songjingchun@126.com
- 基金信息：
- DOI：10.11855/j.issn.0577-7402.1079.2023.1103
  CLC：
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宋景春, 王岗, 房云海, 等. 重症患者凝血酶原复合物合理应用中国专家共识[J]. 解放军医学杂志, 2023, 48(12): 1359-1369.

Song Jing-Chun,Wang Gang,Fang Yun-Hai,et al.Chinese expert consensus on the rational use of prothrombin complex concentrate in critically ill patients[J].Medical Journal of Chinese People′s Liberation Army,2023,48(12):1359-1369.
宋景春, 王岗, 房云海, 等. 重症患者凝血酶原复合物合理应用中国专家共识[J]. 解放军医学杂志, 2023, 48(12): 1359-1369. DOI： 10.11855/j.issn.0577-7402.1079.2023.1103.

Song Jing-Chun,Wang Gang,Fang Yun-Hai,et al.Chinese expert consensus on the rational use of prothrombin complex concentrate in critically ill patients[J].Medical Journal of Chinese People′s Liberation Army,2023,48(12):1359-1369. DOI： 10.11855/j.issn.0577-7402.1079.2023.1103.

摘要

凝血酶原复合物(PCC)是以维生素K依赖性凝血因子为主要成分的血液制品。虽然PCC已在临床应用70多年，安全性已得到明显提升，且已经广泛应用于重症患者凝血功能障碍或大出血的治疗，但若使用方法不当，可能会减弱止血效果或增加血栓形成的风险。为了规范PCC的合理使用，中国医药教育协会血栓与止血危重病专业委员会、全军重症医学专业委员会及中国研究型医院学会血栓与止血专业委员会组织制定此专家共识，包括定义、适应证、监测与评价等3个部分，共10条建议，旨在帮助临床医师合理使用PCC，以提高重症患者救治水平。

Abstract

The prothrombin complex concentrate (PCC) is a blood product that mainly contains vitamin K-dependent coagulation factors. PCC has been used clinically for more than 70 years, and its safety has been significantly improved. It has been widely used in the treatment of coagulation disorders or severe bleeding in critically ill patients. If used improperly, it may weaken the hemostatic effect or increase the risk of thrombosis. In order to standardize the rational use of PCC, Chinese Society of Thrombosis, Hemostasis and Critical Care, Chinese Medicine Education Association, People's Liberation Army Professional Committee of Critical Care Medicine, Chinese Society of Thrombosis and Hemostasis, Chinese Research Hospital Association have organized the formulation of this expert consensus, including three parts: definition, indications, and monitoring and evaluation of efficacy, with a total of 10 suggestions, aiming to help clinicians reasonably use PCC and improve the treatment in critical illness.

关键词

凝血酶原复合物血液凝固因子危重病出血

Keywords

prothrombin complex concentrateblood coagulation factorscritical illnesshemorrhage

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